Cryptococcosis: long-lasting presence of fungi after successful treatment.

Sir, Cryptococcosis is an opportunistic infection caused by Cryptococcus neoformans and is usually seen in immunocompromised patients. Histopathologically, the skin lesions are divided into two types, i.e. cystic and granulomatous lesions (1, 2), each of which occurs exclusively depending on the conditions of individual hosts (3). For unknown reason the titre of cryptococcal antigen in patients’ sera may be persistently positive even after treatment with antifungal therapies (4). We report here an immunosuppressed patient with severe cryptococcosis who had persistent elevation of antigen titre post-treatment and a presence of fungi remaining after clinical improvement.